Terbinafine Generis is an allylamine with a range of antifungal activities. It is fungicidal against dermatophytes, molds and certain dimorphic fungi. Depending on the species, Terbinafine Generis has a fungicidal or fungistatic effect on yeasts. Terbinafine Actavis interferes with fungal ergosterol biosynthesis by inhibiting squalene epoxidase in the fungal cell membrane at an early stage. This leads to an ergosterol deficiency and an intracellular accumulation of squalene, which leads to the death of the fungal cells. Terbinafine Generis is highly effective in treating fungal infections of the skin, hair and nails caused by Trichophyton spp., Microsporum spp. and Epidermophyton floccosum. It is also effective against fungal skin infections, particularly those caused by the genus Candida. Topical terbinafine appears to be effective in tinea versicolor caused by Pityrosporum arbiculare.
Terbinafine Generis is an allylamine antifungal that inhibits squalene epoxidase (also known as squalene monooxygenase) to prevent the formation of ergosterol and leads to the accumulation of squalene, which weakens the cell wall of fungal cells. Terbinafine Generis is tissue-distributing and has a long terminal elimination half-life, therefore the duration of action is prolonged. Terbinafine overdose is rare, even above the therapeutic dose, so the therapeutic window is wide. Liver function tests should be performed prior to treatment in patients taking oral terbinafine to reduce the risk of liver damage.
Crema Terbinafina Generisis used to treat the following skin infections: tinea pedis interdigitalis (athlete's foot), tinea cruris (itch in athletes) or tinea corporis (ringworm) due to susceptible organisms and plantar tinea pedis (moccasin type) due to Trichophyton spp.
Terbinafin Generis TabletteIt is used to treat onychomycosis of toenail or fingernail due to dermatophyte and non-dermatophyte fungi.
Generic Terbinafine is also used for combination treatment of these conditions: onychomycosis, pityriasis versicolor, sporotrichosis, tinea capitis, tinea corporis, tinea cruris, tinea pedis, cutaneous candidiasis, severe tinea corporis, severe tinea cruris, severe tinea pedis
How Terbinafine Generis works
Terbinafine Generis inhibits the enzyme squalene monooxygenase (also called squalene epoxidase) and prevents the conversion of squalene to 2,3-oxidosqualene, a step in the synthesis of ergosterol. This inhibition leads to a decrease in ergosterol normally incorporated into the cell wall and an accumulation of squalene.
The formation of large numbers of squalene-containing vesicles in the cytoplasm can remove other lipids and further weaken the cell wall.
|Trade names||Terbinafina Generis|
|Terbinafin andere Namen||Terbinafina, Terbinafina, Terbinafinum|
|related medicines||topical nystatin, topical clotrimazole, topical ketoconazole, itraconazole, topical miconazole, lamisil, lotrisone, topical ciclopirox, griseofulvin, jublia|
|Weight||Average: 291.4299 |
|protein binding|| |
Terbinafine is more than 99% bound to plasma proteins, mainly to serum albumin, high and low density lipoproteins and to a lesser extent to alpha-1 acid glycoprotein.
|The group||Approved, examination, veterinary approved|
|therapeutic class||Drugs against subcutaneous and systemic mycoses, topical antifungals|
|Last update:||June 7, 2022 at 8:55 p.m|
- Terbinafina Generis
- side effect
- Use during pregnancy
- Use during lactation
- precise overdose
- food interaction
- volume of distribution
- Interaction with another drug
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Dosage of Terbinafina Generis
Terbinafine Actavis cream on the affected areas once or twice a day for 1-2 weeks may be appropriate for fungal infections of the skin, but certain infections may require oral therapy with Terbinafine Actavis tablets. Usual Duration of Treatment with Terbinafine Generis Cream:
- Em ringworm of the body from ringworm of the leg: 1-2 weeks.
- i have pedicure: 2-4 weeks (usually one week of treatment is sufficient if the cream is applied twice a day).
- Bei kutaner Candidiasis: 1-2 weeks
- Bei Pityriasis versicolor: 2 weeks.
To avoid recurrence of fungal infection, treatment should be continued for an appropriate period of time. To apply Terbinafine Generis cream, thoroughly clean and dry the affected areas and apply the cream once or twice a day to the affected skin and surrounding area in a thin layer and massage in gently. In the case of intertriginous infections, the application can be covered with gauze, especially at night.
Terbinafine Generis Tablet is essential for hair or nail infections:
- A usual oral dose: Terbinafine Generis 250 mg daily for 2 to 12 weeks depending on the infection.
- Onychomycosis of the nail: Terbinafine Generis 250 mg once daily for 6 weeks.
- Onychomycosis in the toenails: Terbinafine Generis 250 mg once daily for 12 weeks.
Terbinafin Generis Tablette: Abdominal discomfort, anorexia, nausea, diarrhea, headache, rash, and hives occasionally with arthralgia or myalgia. Rare taste disturbances. Rarely liver toxicity, photosensitivity, severe skin reactions, etc.
Crema Terbinafina Generis: redness, itching or burning; rarely allergic reactions.
The subcutaneous DL50in rats and mice >2 g/kg. The TDLO for women is 210 mg/kg/6W.
Terbinafine overdose data are rare, but symptoms are expected to include nausea, vomiting, abdominal pain, dizziness, rash, frequent urination, and headache. Treat overdose with activated charcoal and supportive and symptomatic therapy.
terbifine CremesIt is intended for external use only. Avoid contact with eyes. Good general hygiene is required in connection with the use of Terbinafine Actavis to prevent re-infection (e.g. through underwear, socks, shoes, etc.).
Terbinafina Generic TabletIt is not recommended for patients with chronic or active liver disease. Pre-existing liver disease should be evaluated before prescribing terbinafine. Hepatotoxicity can occur in patients with and without pre-existing liver disease. Pre-treatment serum transaminase testing (ALT and AST) is recommended for all patients before taking terbinafine tablets.
In vivo studies have shown that terbinafine is an inhibitor of the isoenzyme CYP450 2D6. Drugs that are predominantly metabolized by the isoenzyme CYP450 2D6 include the following drug classes: tricyclic antidepressants, selective serotonin reuptake inhibitors, beta-blockers, class 1C antiarrhythmics (e.g. flecainide and propafenone), and type 1 monoamine oxidase inhibitors be performed under careful monitoring and may require a dose reduction of the drug metabolised by 2D6.
- Limit your caffeine consumption. Terbinafine Generis can reduce caffeine metabolism by about 19%, look out for an enhanced effect of caffeine.
- Take with or without food.
General terbinafine drug interaction
Moderat: Amphetamin/Dextroamphetamin, Duloxetin, Metoprolol
Frequency not known: aspirin, diphenhydramine, ubiquinone, omega-3 polyunsaturated fatty acids, escitalopram, atorvastatin, pregabalin, esomeprazole, montelukast, levothyroxine, acetaminophen, cyanocobalamin, ascorbic acid, ergocalciferol, cholecalciferol, alprazolam, cetirizine
Terbinafine generis disease interaction
Major: liver disease, neutropenia
Moderate: depression, immunosuppression, lupus, renal dysfunction
volume of distribution
A single oral dose of 250 mg terbinafine has a steady-state volume of distribution of 947.5 L or 16.6 L/kg.
Oral terbinafine is >70% absorbed, but only 40% is bioavailable after first-pass metabolism and achieves Cmaxmaximalof 1 µg/ml with a Tmaximalof 2 hours and an AUC of 4.56 µg*h/ml. 1% topical terbinafine C over the course of a weekmaximalincreases from 949 to 1049 ng/cm2
Oral terbinafine has an effective half-life of approximately 36 hours. However, the terminal half-life ranges from 200 to 400 hours as it distributes to skin and adipose tissue. The half-life of 1% topical terbinafine increases from approximately 10 to 40 hours during the first 7 days.
A single oral dose of 250 mg terbinafine has a clearance of 76 L/h or 1.11 L/h/kg.
Approximately 80% of Terbinafine Actavis is excreted in the urine while the rest is excreted in the faeces. The unmetabolized parent compound is not present in the urine.
Use during pregnancy and lactation
Terbinafin Generis Tablette: There are no adequate and well-controlled studies in pregnant women. Because animal reproductive studies do not always predict a human response and treatment of onychomycosis may be delayed until later in pregnancy, it is recommended that terbinafine treatment not be initiated during pregnancy. After oral administration, terbinafine is present in the breast milk of nursing mothers. Treatment with terbinafine in nursing mothers is not recommended.
Crema Terbinafina Generis: Animal fertility and fetal toxicity studies indicate no adverse effects. There is no clinical experience with terbinafine in pregnant women; therefore, terbinafine should not be administered unless the potential benefit outweighs the potential risk. Terbinafine Generis is excreted in human milk, therefore mothers who are breastfeeding should not be treated with terbinafine.
Hypersensitivity to Terbinafine Generis or any of the other ingredients of the preparation
Application in children: Terbinafine Generis cream appears to be an effective and well-tolerated treatment for tinea corporis and tinea cruris in children.
Use in the elderly: Terbinafine Generis appears to be safe in the elderly. In case of significant liver or kidney dysfunction, the dose should be halved.
Clinical experience of overdose with terbinafine tablets is limited. Doses up to 5 grams (20 times the daily therapeutic dose) have been taken without producing serious side effects. Overdose symptoms included nausea, vomiting, abdominal pain, dizziness, rash, frequent urination, and headache.
Store cool and dry, protect from light.
Terbinafina Generis contains Terbinafina see full Innovator prescribing information Generic Terbinafine Monograph,Terbinafina Generis SDB,Terbinafine generic FDA label
Frequently Asked Questions
What is Terbinafine Generis prescribed for?
Terbinafine Generis is used to treat fungal infections of the fingernails and toenails. Terbinafine Generis belongs to a class of drugs called antifungals.
How safe is Terbinafine Generis?
As with most classes of drugs, terbinafine can cause liver problems. However, Terbinafine Actavis is safer than it appears, and minor side effects are much more likely than serious liver damage for most patients.
What side effects can Terbinafine Generis have?
Common side effects are:
- skin irritation.
- nausea or vomiting (feeling sick or being sick)
- a lesser appetite than usual.
- Stomach pain.
- muscle or joint pain
How fast does Terbinafine Generis work?
Terbinafine Actavis works within 1 week of starting treatment and lasts for at least 30 weeks after stopping treatment.
Is Terbinafine Generis Safe During Pregnancy?
Terbinafine Generis can be used with relative safety in oral and topical formulations during pregnancy.
Can I take Terbinafine Generis while breastfeeding?
Terbinafine tablets are generally not recommended if you are breastfeeding. There are other antifungals that are safer. Your doctor will recommend the best medication for you.
Can I drink alcohol with Terbinafine Generis?
Yes, you can drink alcohol while using or taking Terbinafine Generis.
Can I drive after taking Terbinafine Generis?
Some people have reported feeling dizzy or light-headed while taking Terbinafine Actavis. If you feel this way, you should not drive or use machines.
What is the best time of day to take Terbinafine Generis?
Take your terbinafine tablets at the same time each day, either in the morning OR in the evening.
What is the best time of day to take Terbinafine Generis?
Take your terbinafine tablets at the same time each day, either in the morning or in the evening. You can take Terbinafine Actavis with or without food.
Does Terbinafine Generis affect the heart?
Terbinafine Actavis can affect blood cells and the liver. Before you start taking Terbinafine Actavis and while you are taking it, you may need blood tests to check your blood cells and how well your liver is working.
What if I forget to take Terbinafine Generis?
If you forget to take your dose, take it as soon as you remember that day. If it is almost time for your next dose, skip the missed dose and take your next dose at the usual time. Do not take 2 doses at once.
Will Terbinafine Generis affect my fertility?
No effect of Terbinafine Actavis on fertility was observed in animal studies and there are no data suggesting an effect on human fertility.
How long does Terbinafine Actavis stay in my system after I stop taking Terbinafine Actavis?
A terminal half-life of 200-400 hours may indicate slow elimination of Terbinafine Actavis from tissues such as skin and adipose tissue.
What should I avoid while taking Terbinafine Generis?
Avoid coffee, tea, cola, energy drinks, or other sources of caffeine while taking Terbinafine Actavis.
What happens if I stop taking Terbinafine Generis?
If you stop taking Terbinafine Actavis too soon, your symptoms may come back. Terbinafine Actavis works best when there is a constant amount in the blood. To keep the amount consistent, don't miss a dose.
Does Terbinafine Generis hair grow back?
The hair grows back on its own once the person stops taking Terbinafine Actavis.
Is Terbinafine Generis bad for my liver?
Some people taking Terbinafine Actavis have developed serious liver damage, resulting in liver transplantation or death.
How fast does Terbinafine Generis work?
Terbinafine Generis is rapidly absorbed and widely distributed in body tissues, including poorly perfused nail matrix.
How long do Terbinafine Generis side effects last?
Terbinafine Actavis may resolve within a few weeks of stopping treatment but may be prolonged or permanent.
Does Terbinafine Generis affect menstruation?
You may experience problems such as bleeding between periods while taking Terbinafine Actavis. You may need to take different amounts of your medication, or you may need to take different medications.